Compare Weight Loss Injections UK

In clinical trials, tirzepatide (Mounjaro) has produced the largest average weight loss of the three, followed by semaglutide (Wegovy), then liraglutide (Saxenda). Average trial results are not a prediction for any individual, though. Which treatment is most effective for you depends on your medical history, how well you tolerate the medicine, whether you can commit to weekly or daily injections, and what you can sustain financially. That decision is made with a prescriber, not from a table.

Both are GLP-1 receptor agonists, but they use different active ingredients and different dosing schedules. Wegovy contains semaglutide and is injected once a week. Saxenda contains liraglutide and is injected once a day. Average weight loss in clinical trials is higher with Wegovy, and the weekly schedule suits many people better, but tolerability varies from person to person.

Switching between treatments is possible, but it has to be done under the supervision of a prescriber. The two medicines are not interchangeable dose for dose, so a prescriber will normally stop one before starting the other and begin the new treatment at its lowest starting dose, escalating from there. Never run two GLP-1 treatments at the same time, and never carry a dose across from one to the other on your own.

Some are, but access is restricted and the criteria are strict. NHS prescribing generally depends on your BMI, whether you have weight-related health conditions, and referral through a weight management service, and availability differs across England, Scotland, Wales and Northern Ireland. Waiting times can be long, which is why many people look at private prescription services instead. Your GP is the right starting point for checking whether you qualify.

Yes. All three are licensed as an addition to a reduced-calorie diet and increased physical activity, not as a replacement for them. The trial results these medicines are measured against were achieved alongside those changes. Diet and activity also protect muscle mass while you lose weight, and give you something to hold on to if you come off treatment later.