Mounjaro vs Wegovy: Which is Better?
A detailed comparison of the two leading weight loss injections.
| Feature | Mounjaro | Wegovy |
|---|---|---|
| Active Ingredient | Tirzepatide | Semaglutide |
| Mechanism | Dual Agonist (GLP-1 + GIP) | GLP-1 Agonist |
| Avg Weight Loss | Up to 22.5% | Up to 15% |
| Frequency | Weekly | Weekly |
| Starting Price | ~$199 | ~$249 |
Mechanism of Action
Mounjaro
Mounjaro is the first "dual agonist" medication. It mimics two hormones: GLP-1 and GIP. This dual action is believed to be the reason for its superior weight loss results in clinical trials.
Wegovy
Wegovy mimics a single hormone: GLP-1. It has been used for longer and has a well-established safety profile. It is highly effective, though slightly less so than Mounjaro on average.
Effectiveness
In a head-to-head clinical trial (SURMOUNT-1 vs STEP trials comparison), Mounjaro demonstrated greater weight loss than Wegovy. Patients on the highest dose of Mounjaro lost an average of 22.5% of their body weight, compared to around 15% for Wegovy.
However, both medications are significantly more effective than diet and exercise alone, or older weight loss medications like Saxenda.
Cost Comparison
Mounjaro is often priced similarly or slightly lower than Wegovy, with starting prices around $199 compared to $249 for Wegovy depending on the provider and insurance coverage. Prices vary by pharmacy and dose.
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